Swiss surgeons have successfully used nose cells to repair damaged knee joints, according to a study released Thursday by the journal The Lancet.
"The treatment is safe and feasible," study co-author Dr. Ivan Martin told CNN.
Between 2004 and 2011, nearly 2 million Americans had knee surgery due to cartilage problems. As the population ages, these surgeries will become increasingly common.
Martin, a professor of surgery and biomedicine at University Hospital Basel in Switzerland, has been working on a new way to repair knees since 2001. His latest procedure uses engineered cartilage tissue grown from the nasal septum of the patient. He said that nasal cells “have a larger and more reproducible capacity to form new cartilage.”
"We further established that the cartilage tissue generated by nasal chondrocytes (one type of cell) can respond to physical forces (mechanical loads) similar to articular cartilage and has the 'plasticity' to adapt to a joint environment," Martin told CNN. In one of their pre-tests for the current study, he implanted engineered tissue into goat joints and found it "efficiently integrated with surrounding articular cartilage."
For the new study, Martin used 10 patients from 18 to 55 that had cartilage problems in their knees. The team extracted a 6-millimeter biopsy specimen from the nasal septum, using local anesthetic. Then the harvested celled were exposed to growth factors for two weeks.
After an additional two weeks, Martin’s team was able to craft a 30-by-40 millimeter cartilage graft. Surgeons then implanted it as a replacement for damaged knee cartilage.
None of the patients reported side effects related to the experimental surgery. CNN reported.
Smoking scars DNA in clear patterns, researchers reported this week. And while most of the damage fades after five years if people quit smoking, researchers found that not all of it does.
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NBC News reported that information based on a study of 16,000 people. The patterns are made in a process called methylation, which is an alteration of DNA that can inactivate a gene or change how it functions — often causing cancer and other diseases, researchers said.
Heart disease and cancer are caused by genetic damage — some of it inherited, but most of it caused by day-to-day living. Smoking is one of the biggest causes, researchers said.
The research team examined blood samples given by 16,000 people taking part in various studies since 1971. In all of the studies, people have given blood samples and filled out questionnaires about smoking, diet, lifestyle and their health histories.
They found smokers had a pattern of methylation changes affecting more than 7,000 genes, or one-third of known human genes. Many of the genes had known links to heart disease and cancers known to be caused by smoking.
Smoking is the biggest cause of preventable illness, killing more than 480,000 Americans every year, according to the Centers for Disease Control and Prevention.
A French woman, who was the world’s first recipient of a face transplant, died in April “after a long illness,” hospital officials said Tuesday.
Isabelle Dinoire, 49, lost her nose and mouth after a dog bite. She made medical history on Nov. 27, 2005, when she was given a partial face transplant using tissue from a brain-dead woman during a 15-hour operation at Amiens Picardie hospital.
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Hospital officials in Amiens confirmed Dinoire’s death, explaining that the delay in announcing her passing was “in accordance with the will of her relatives,” who wished to protect their privacy.
Although doctors did not elaborate on the cause of death, the French media reported that Dinoire had suffered complications following her latest surgery. Le Figaro reported that Dinoire’s body had rejected the transplant last year “and she had lost part of the use of her lips.”
At the age of 38, Dinoire received a triangular-shaped graft, comprising the nose, lips and chin, to replace parts of her face that had been mauled by Tanya, her pet cross-Labrador.
For months before the transplant, she had “the face of a monster,” she said. She had no mouth and her teeth and gums were exposed.
After her surgery, Dinoire said she was determined to make a success of her life, learning to eat and speak and also wanting to be able to kiss.
Since Dinoire’s surgery, more than 30 people worldwide have had similar treatment.
An Indiana dentist and patient are going back and forth over a dentist appointment gone terribly wrong.
Donny Grigsby said he recently went to White River Dental in Columbus, Indiana, to have four teeth removed, and when he woke up, he had no teeth.
Now, Dr. Aaron Strickland, Grigsby’s dentist, says his patient is lying.
In an exclusive interview with WXIN on Sunday, Strickland presented a consent form for a full mouth teeth extraction signed by Grigsby on March 15. Strickland says Grigsby signed the document with encouragement from his wife, Amanda, before the procedure began.
“The claims that we have got are false accusations,” Strickland told reporters. “They’re malicious. The whole thing feels like an extraction extortion.”
Grigsby’s wife claimed that after several hours in the waiting room, she wanted to know what was going on with his procedure. She said doctors told her that they were scared the infection would spread from one tooth that was abscessed. They were expecting Strickland to pull only four teeth.
“There is blood all over him, all over his shirt,” she told WRTV, “and my husband is droopy eyed, not responsive.”
Strickland said, “Donny had multiple large cavities in almost every tooth,” and “the cavities were so extensive that they were into the nerves of multiple teeth.” After laying out the treatment options to Grigsby, “Donny signed the treatment plan and an Oral Surgery Consent Form for a full mouth extraction," Strickland said.
Strickland also claims that Grigsby failed to mention health history such as being on blood thinners, or his history of blood clotting when filling out his medical history form.
“It would have been good to know if he was on blood thinners, or if he wasn’t on blood thinners because either way it tells us there was some other historical issues going on,” Strickland told WXIN. “And neither one was discussed.”
According to the reports, Strickland and his legal team are seeking a court order to allow him to comment in full detail about all of his interactions with the Grigsbys.
It’s like a scene from a horror movie.
An Indiana man is demanding answers after waking up from a routine dental procedure with no teeth in his mouth.
“I am so ashamed now,” Donny Grigsby told WRTV. “I have no teeth.”
Grigsby's wife, Amanda, said that after five hours of waiting at White River Dental, she learned that the dentist decided to pull all of Grigsby's teeth because he was afraid an infection would spread.
Amanda said she found Grigsby covered in blood. While at the dentist's office, they called an ambulance. She said that on the way to the hospital, he "coded" twice.
Grigsby is now back at home, still on oxygen after the procedure, according to WRTV.
A Pennsylvania veterinarian had a very creative solution for a goldfish whose jaw problems prevented it from being able to eat properly.
Dr. Brian Palmeiro at Lehigh Valley Veterinary Dermatology crafted a small mouth brace for the goldfish, named Mr. Hot Wing, out of a piece of a credit card.
Mr. Hot Wing, who was born without a jawbone and couldn’t keep his mouth open, had been suffering from breathing problems and an inability to eat. Now, he's able to do both.
A picture of the fish with the "braces" posted on Lehigh Valley Veterinary Dermatology's Facebook page went viral before being deleted.
The surgery cost Mr. Hot Wing's owner around $150, Mashable reported.
Palmeiro has also performed other procedures on fish, like one on a goldfish to remove skin tumors and another on a pleco fish for which he crafted a sling to support a dislocated pectoral fin.
One of our recent goldfish patients that came in for numerous large skin tumors. Doing great 1 week after surgery!Posted by Lehigh Valley Veterinary Dermatology on Friday, November 6, 2015
Alice the pleco visited us today for a dislocated right pectoral fin that wouldn't move, preventing her from going into...Posted by Lehigh Valley Veterinary Dermatology on Monday, November 16, 2015
Model Mieko Rye has struggled with her self-confidence ever since she began chemotherapy treatments.
Now, she's hoping to help other women who are battling cancer feel empowered.
"When I first started to lose my hair and my eyebrows and eyelashes, I thought, 'This situation is so sick with irony because of my job,'" Rye told ABC News. "I would say it jokingly to people but I was really crying on the inside. I think that was the first step on my journey."
At one point, the 41-year-old decided no woman should ever feel the way she did. That's when she decided to pose for a photoshoot and post the pictures to Facebook. Her aim was to encourage and inspire other "pink ladies."
“With cancer comes destruction," Rye wrote in the post. "However, it has also provided me with the opportunity to rebuild from the inside out. I have shed what is no longer necessary and quite honestly, impeded my growth.
Rye noted that when she first started modeling 20 years ago, women of color did not embody the “American concept of beauty.”
“I was told I was too dark, too light, too curvy, or that my hair was too dry, too curly, or too big,” she wrote on Facebook. “Then the curvy Brazilian girls took over the fashion industry, God bless them, and my career took off.”
When she was diagnosed with cancer, she faced similar adversity:
"Many of the celebrated parts of a woman that our culture defines as beauty I no longer have: eyebrows, hair, eyelashes," Rye wrote. "Chemotherapy wreaks havoc on your body slowly. My sum of parts once interconnected and harmonious are now dissembled and out of tune."
And yet, Rye said cancer has helped her become confident and comfortable with being “alone:”
“When I say I am alone, I mean free of a man, career, role, or title I may have clung to in the past to define myself," she wrote. "My happiness does not depend on the love, reassurance, loyalty, or approval of another. I am simply Mieko. I have nothing to hide. I have stage 3 breast cancer, and I have never felt more beautiful in my entire life.”
Rye plans to have a bilateral mastectomy soon -- a decision she said was inspired by her 7-year-old son.
"I'm more happy now because I know myself so much better and I love myself so much more," she told ABC. "I'm going to own this and I want other women to be inspired and own it as well. It's more about the inner beauty and when that shines through, you're just as beautiful. You haven't lost anything. You've gained it."
I had this idea to do a photo shoot while battling cancer. When I first began my career as a model 20 years ago I did...Posted by Mieko Rye on Wednesday, January 6, 2016
Posted by Mieko Rye on Monday, October 6, 2014
Posted by Mieko Rye on Saturday, January 12, 2013
Posted by Mieko Rye on Monday, December 8, 2014
Teething — it’s happened to all of us and none of us remember it, but everyone knows it makes babies cry.
While the actual process is much longer and arguably more painful, it only takes an unusual time-lapse video 20 seconds to show just why that’s the case.
(H/t Mental Floss)
Etubics Corporation, a biopharmaceutical company in Seattle’s Lower Queen Anne neighborhood, is moving forward after a major breakthrough in treating cancer patients. A new type of treatment more than doubled the life span of some cancer patients.
Now, the lab has the backing of the National Cancer Institute in testing its immunotherapy for cancer patients.
Etubics more than doubled the life span of advanced stage colorectal cancer patients using a new vaccine with a new delivery method. Now NCI will spend tens of millions of dollars in Phase 1, 2, and 3 clinical trials.
“We anticipate the results are going to be even better, and I'll tell you why,” said Dr. Frank Jones, Etubics CEO. “The National Cancer Institute is giving us two more drugs that we'll be adding to the drug we used in our trials.”
Biopharmaceutical companies are able to use vaccines to give a cancer patient cells that attack the cancer cells, but the vaccine is only part of the story.
The new treatment will be used beyond surgery, radiation, and chemotherapy. Previously they had to take cells out of the cancer patient's body, then apply the vaccine, and put the cancer killer cells back into the patient's body. So this is another major advancement. The new delivery method is just like a flu shot. It’s a one-time shot of the vaccine right into the patient's body to induce cancer killer cells.
Under the new trials, they're targeting more types of cancer.
“We'll be able to treat a lot more kinds of cancer, lung cancer, breast cancer and colon cancer,” said Jones. “If all goes well, and we hope it does, we should have it in the hands of oncologists within three years.”
A group of physicians have recently criticized Dr. Oz for his alleged shortcuts around medical issues. Specifically their claim says Dr. Oz exhibts "an egregious lack of integrity by promoting quack treatments and cures in the interest of personal financial gain."
The group of physicians sought to have Oz, whose first name is Mehmet, removed as the vice chair of Columbia University's Department of Surgery.
In an exclusive to Time, Oz fired back over what appears to be a difference in philosophies.
Oz says that he has been working for years to get GMO labeling on foods that fit the category. He notes that the lead author of the letter asking for his ouster, Dr. Henry Miller, is on the pro-GMO side and has led efforts to block GMO labeling in California.
"As a scientist, I am not that concerned about GMOs themselves, but I am worried about why they were created," Oz writes in Time. He believes the gratuitous chemicals could be harmful to humans and believes consumers should be informed about the products they buy.
A handful of the letter's authors are also linked to big tobacco industries as potential allies, according to Oz.
The letter's authors, as well as the British Medical Journal, have said Oz has made medical claims that are not backed by evidence.
Oz, who is a cardiothoracic surgeon, addressed the critics on his Thursday show and because of it will inevitably reach more people than the 10 physicians who wrote the letter.
A communications official at Columbia University told the New York Times the school "is committed to the principle of academic freedom, which means our faculty are encouraged to participate in public discussion."
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